Researchers from Northwestern University have developed a method to rewire immune cells by genetically modifying the cells to sense molecules secreted by tumors and respond by activating the immune system. The team’s work is described in a study published this month in Nature Chemical Biology.
Although immunotherapy is growing in popularity among cancer researchers, tumors secrete molecules that render most immune cells inactive. “Right now, one of the most promising frontiers in cancer treatment is immunotherapy – harnessing the immune system to combat a wide range of cancers,” senior author Joshua Leonard said in prepared remarks. “The simple cell rewiring we’ve done ultimately could help overcome immunosuppression at the tumor site, one of the most intransigent barriers to making progress in this field.”
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